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Patients with TBI typically require substantial fluid replacement and resuscitation.
If substantial fluid loss is anticipated, calculation of fluid replacement requirements can be estimated by weighing the animal before and after the procedure.
In highly porous scaffolds subject to cyclic strain, the mechanical deformations can induce substantial fluid pressure gradients, which affect the transport of solutes.
Substantial fluid overload is therefore indeed a prevalent problem in PD patients, and more attention should be given to its assessment and correction.
Conversely, substantial fluid movements between ICW and ECW have been reported during chronic hemodialysis [ 20, 27, 39, 42].
Changes in Vd have been observed with other β-lactams in critical illness [ 26] and likely reflect the substantial fluid shifts frequently encountered [ 27].
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However, frequent recalibration is time-consuming, might result in inaccuracies itself and in a substantial fluid-load.
Indeed, despite a lower sodium concentration in RL than in HSL (Table 1), the more-substantial fluid infusion required led to a superior sodium load in the RL group.
This phenomenon suggests that earthquakes in the crust are facilitated as a result of substantial pore fluid generated by dehydration reactions to eclogite from hydrous minerals (e.g., Abers et al. 2013).
It is also found that not all the particles are deposited on the substrate perpendicularly (even if the spray angle is 90°), due to substantial radial fluid velocities near the stagnation point.
In the present study, we conducted a more comprehensive evaluation of the relationships among variations in geology, geochemistry, and microbial metabolisms and the diversity of communities in global deep-sea hydrothermal environments, based on compilation of a substantial hydrothermal fluid chemistry data set and microbial communities in the mixing zones of a wide variety of habitats.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com