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Three commonly used variant detection tools, SAMtools, Dindel, and GATK's Unified Genotyper, all had substantial false positive rates for indels.
Each program had substantial false positive and false negative rates in at least one of the three CNV regions tested.
Several authors have noted the large-scale variability between CNV-detection methods, as well as the substantial false positive and false negative rates associated with those methods.
Several authors have noted the large-scale variability between CNV-detection methods, as well as the substantial false positive and false negative rates associated with those methods (e.g., Winchester et al. [4], Zhang et al. [5]).
This set of protein identification parameters threshold did not return any substantial false positive protein hit from the randomized half of the concatenated database.
In addition, cervical cytology is associated with a substantial false positive rate that may create an overload in the work schedule of the limited available colposcopic units, causing a delay in the referral of true positive cases for colposcopic evaluation and leading to over-treatment, which is inevitably accompanied by anxiety, morbidity and monetary costs (Beutner et al, 1998).
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They found that very diverse outputs are often generated when the same gene expression data is analyzed using different algorithms, i.e., low overlap and substantial false positives.
In addition to clarifying substantial false positives in the widely used University of California Santa Cruz (UCSC) annotations, our study identifies numerous novel epigenetic loci.
Although some X-linked miRNAs have non-conserved seed sequences, for many miRNAs, the prediction of non-conserved targets will yield substantial false positives that could hinder meaningful functional comparison between target gene sets.
However, there are substantial false-positive and false-negative findings when evaluating bone metastasis without SPECT/CT [27 31].
MDA WGA produces wgaDNA from no template control samples; such samples exhibited substantial false-positive genotyping rates.
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