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In the case of System 5, the probable cause of the high number of falsely detected speakers lies in the substantial false alarm rate (FA error, see Table4) of the speech/non-speech detection rather than clustering algorithm, because speaker error rate (SPKE) is very good compared with other systems.
Each program had substantial false positive and false negative rates in at least one of the three CNV regions tested.
Several authors have noted the large-scale variability between CNV-detection methods, as well as the substantial false positive and false negative rates associated with those methods.
Several authors have noted the large-scale variability between CNV-detection methods, as well as the substantial false positive and false negative rates associated with those methods (e.g., Winchester et al. [4], Zhang et al. [5]).
Baross et al found considerable variation among the outputs from different programs, as well as substantial false call rates for CNVs, when they compared four CNV detection programs [20]: Copy Number Analyser for GeneChip® arrays (CNAG) [21], DNA-Chip Analyzer (dChip) [22], Affymetrix GeneChip® Chromosome Copy Number Analysis Tool (CNAT [20], [23] and Gain or Loss Analysis of DNA (GLAD) [24].
Across the mtGenome, there were 296 GG homopolymers of which only 16 were associated with substantial false deletions.
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However, there are substantial false-positive and false-negative findings when evaluating bone metastasis without SPECT/CT [27 31].
MDA WGA produces wgaDNA from no template control samples; such samples exhibited substantial false-positive genotyping rates.
High variability in findings exists among CNV detection methods, along with substantial false-positive and false-negative rates [ 38].
Most melanomologists think that the extra prognostic information and the recently established survival benefit in node-positive patients outweigh the limited morbidity and the substantial false-negative rate.
Single site evaluation to detect prognostic gene mutations, even with multiple samples obtained at that site, may lead to substantial false-negative marker assessments; this represents an impediment to clinically relevant tissue sampling.
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