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Likewise, DNA methylation has been significantly associated with baseline HbF [38, 46, 47] but provided no substantial explanation for HbF induction in response to HU.
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In Model IV, except for age and gender, all other predictors were able to provide substantial explanations of EQ-5D scores (p < 0.05).
Except for 'western lifestyle' no substantial explanation has been offered to explain this divergence.
Conventional risk factors, such as smoking, hypertension, and hyperlipidemia provide a substantial, yet, limited explanation for the increased risk of CVD in DM [ 2].
The fact that both viruses share the same route of transmission, through sexual contact, makes it challenging to disentangle biological from behavioral mechanisms as confounding by sexual behavior [52], [78], [79], [80] may be one explanation for the substantial variability in study outcomes [23], [24].
3 Thus, there is no plausible explanation for the substantial higher alcohol attributable fraction for liver cancer based on risk estimates computed in those who had never smoked.
An alternative explanation for the substantial variation observed among V. cholerae isolates from Kenya is that their tandem repeat loci may result from a rapid accumulation of mutations.
Another possible explanation for the substantial enhancements in allosteric effectiveness observed with the single and double variants is that these residues are in fact involved in multiple allosteric networks.
The process evaluation provides a possible explanation for the substantial inter-village variation in the impact of the intervention by showing that the quality of the intervention was lower in the first three villages in which it was delivered, which is also where the observed change in HWWS was lowest.
A potential explanation for the substantial effect of influenza B/Malaysia-like viruses observed post-WYD2008 is reduced community immunity to influenza B. In 2007, influenza B was an infrequent pathogen (6.9% of total isolates typed); influenza A (H3N2) and A (H1N1) viruses were most frequently detected (58.7% and 34.4% of total isolates typed or subtyped) (21 ).
This is not to say HRX is wrong as an explanation for settings where substantial disparities are found, only that there is insufficient evidence to suggest HRX, under SSM, provides a plausible and creditable motivating framework for some of Scanlan's settings of interest.
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