Sentence examples for substantial exacerbation from inspiring English sources
We present two children diagnosed with epilepsy with myoclonic-astatic epilepsy (MAE) who experienced a substantial exacerbation of their myoclonic and atonic seizures following initiation of treatment with LEV and improvement following discontinuation of this AED.
The cumulative effect of this 'lost decade' of debate, discussion, and deliberation was a substantial exacerbation of the risk, cost, and time it took to develop new antibiotics, just at the time when scientific challenges and other economic realities were having the same effect.
Of the four children subsequently treated with add-on LEV, two had no change in seizure frequency while two others, which are the basis of this report, had a substantial exacerbation in the frequency of their myoclonic and atonic seizures following the introduction of this drug.
Secondary end points included significant exacerbations requiring systemic corticosteroids, all exacerbations, and changes in FEV1.
Our study indicates that a substantial amount of exacerbations remain partly or completely unmanaged.
Thus, it would seem appropriate to identify AR in asthmatic subjects, especially for occupational physicians given the substantial risk of asthma exacerbation in the workplace.
"Our findings suggest that by decreasing automobile emissions through citywide changes in transportation and commuting practices," the authors wrote, "a substantial number of asthma exacerbations requiring medical attention can be prevented".
CCQ monitoring is a promising low burden method to detect a substantial proportion of unreported exacerbations.
A recently completed audit of patients hospitalized for COPD exacerbations found substantial variations in care, with spirometry prior to hospital admissions available in only about three-quarters of patients [ 8].
Patients with COPD admitted to an ICU for an acute exacerbation have a substantial hospital mortality (24%) that has been associated with the development of nonrespiratory organ system dysfunction and exacerbation of the underlying respiratory disease [ 20].
Although we have no estimate of productivity loss due to a decrease in functioning at work for our study participants, the high prevalence of work-related symptom exacerbation suggests a substantial decrease in productivity might have occurred.
