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The cost to communities and the impact on their development is substantial, estimated to account for billions of dollars in lost productivity, reducing potential economic growth that would lift people out of poverty.
In addition, the material to construct the forts was substantial, estimated at 1 million cubic feet (28,315 m3) of timber during the 1st century.
The financial cost of falling is also substantial, estimated at nearly £1 billion per annum.
As well as the personal costs of unemployment the financial costs to the government are substantial, estimated to be £3.4 billion in 2005 for those with schizophrenia [ 6].
Screening costs were substantial, estimated at £59,900 or £165 per participant eventually recruited into the study (Supplementary data are available in Age and Ageing online).
The costs of neonatal intensive care days are substantial, estimated at $1300 day (public) for an average NICU 2 day and $2500 per day (public) for an average NICU 3 day.
Similar(51)
When disease burdens are large and the call upon resources is substantial, estimates need to be as accurate as possible.
The risks posed may be substantial; estimates from the Clean Air for Europe (CAFE) framework program indicate that approximately 350,000 premature deaths per year in the European Union can be attributed to exposure to PM [ 5].
Given the substantial estimates of variance explained, then with sufficient sample size it should be possible to construct a reasonable prediction model for epilepsy using genome-wide SNP data.
Contrary to this, and in agreement with other studies using adults, 20 30 including a preliminary study of this sample, 10 our estimates gave significantly higher tetrachoric correlations in monozygotic versus dizygotic twins (0.641 vs 0.375, p<0.02 for difference) and substantial estimates of heritability.
Apologies, costs and very substantial damages (estimated at £350,000) followed.
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