"DuPont has made a substantial effort to recast itself and move into the life sciences and away from the commodity chemical business," Mr. Hittle said.
"Damage is significant to both tracks and overheard wires," Mr. Donovan said, adding that it would "take a substantial effort to repair".
Even the biggest electronics companies have had to mobilize substantial effort to comply with the Dodd-Frank Act's requirement to report their use of conflict minerals.
Participants agreed on the need to address this problem by making an immediate and substantial effort to build co-operation and promote reconciliation between groups, as well as between the centre and the regions.
Nonetheless, for all its apparent simplicity, "Avengers: Age of Ultron" is a serious moviegoing experience — and that seriousness, Whedon's earnest, thoughtful, substantial effort to wrench the comic-book movie into the age of adulthood, is the problem.
Such a transformation could pay huge strategic dividends for American foreign policy, but it would also require a substantial effort to rebuild Iraq, including the development of new governing institutions.
A network can only push out so much data at any given time and operators expend substantial effort to ensure that no subscriber is entirely cut out by pinching bandwidth from extant connections, slowing them down.
In February MBIA, an embattled bond insurer, complained to a congressional committee that "self-interested parties have gone to substantial effort to undermine the market confidence that is critical to MBIA's business".
If I want to seriously look for work in another field it would require substantial effort to redirect my profile, as well as accepting that many of my hard earned skills and achievements are irrelevant outside academia, and may even intimidate prospective employers.
One modest example is the lack of substantial effort to retrofit or replace hundreds of schools in the state of Oregon that engineers have identified as likely or nearly certain to collapse when the next inevitable great earthquake is triggered along the region's Cascadia fault (there are struggles to prepare coastal communities for the inevitable tsunami, as well).
But the substantial effort to manifest that passion put it at arm's length.
