Sentence examples for substantial efficacy from inspiring English sources

Pegylated liposomal doxorubicin has shown great prolonged circulation and substantial efficacy in breast cancer treatment [7].

Preliminary in vitro results revealed that 2b and 2m displayed substantial efficacy as potent antivascular agents.

Adalimumab is a human monoclonal antibody against tumor necrosis factor-alpha (TNF-α) that has demonstrated substantial efficacy when used for the treatment of several immune-mediated diseases [2, 3].

A systematic review of licensed influenza and pneumococcal vaccines showed substantial efficacy in children, but the health-economic impact of such vaccines among pre-school children with recurrent RTIs is unknown.

PREEMPT supports the efficacy and tolerability of onabotulinumtoxinA for the prophylaxis of headache in adults with CM.[1] These data demonstrate that onabotulinumtoxinA treatment results in a significant 75% reduction in multiple headache symptom measures and highly substantial efficacy for a subpopulation of patients studied.

Here we demonstrate that substantial efficacy improvements can be achieved through further refinement of siRNA chemistry, optimizing the positioning of 2′-deoxy-2′-fluoro and 2′-O-methyl ribosugar modifications across both strands of the double-stranded siRNA duplex to enhance stability without compromising intrinsic RNAi activity.

However, substantial clinical efficacy has been shown in hematological malignancies treated with second-generation CARs (Kochenderfer et al., 2010; Porter et al., 2011; Kalos et al., 2011; Wang et al., 2014; Maude et al., 2014a; Davila et al., 2014; Dai et al., 2015; Lee et al., 2015a; Kochenderfer et al., 2015; Porter et al., 2015; Turtle et al., 2016a; Wang et al., 2016; Zhang et al., 2016a).

Raltegravir has demonstrated substantial clinical efficacy in treatment-experienced HIV-1 patients.

Power savings were substantial, and efficacy was found to be superior to standard stimulation.

Yet, such a strategy should still demonstrate both substantial preclinical efficacy without tumorigenicity before human translation.

The model requires updating, as substantial new efficacy data have been published in the form a meta-analysis.