Sentence examples for substantial drawbacks with from inspiring English sources

As a result of this, the Marshall Mix design procedure has substantial drawbacks with respect to replicating the real or actual behaviour of asphalt during construction and in actual in-service conditions.

There may be significant drawbacks with this method, however.

Compared with standard pulse sequences such as FLAIR and T2 TSE, substantial drawbacks of DIR applications at 1.5 T are the higher propensity to produce artefacts (in particular because of vessel and CSF flow) but also the relatively low SNR due to the application of two consecutive inversion pulses.

Amiri (2006) introduces capacity levels available to potential warehouses and plants and resolves substantial drawbacks of previous strategic approaches.

However, many of the current methods present substantial drawbacks which can limit their application and confound results.

While for most candidates these would be substantial drawbacks, Ted Cruz is not most candidates.

Means of detection other than PCR also have substantial drawbacks.

6 8 23–36 These are substantial drawbacks for using steroids to treat macular oedema in CRVO.

However, CT has substantial drawbacks leading to an almost complete replacement of this imaging technique by US and MRI.

Thus, despite their substantial drawbacks lung histology and collagen content determinations remain the established means of assessing bleomycin-induced dysfunction.

However, current methods for analyzing allelic RNA expression from RNA-Seq have substantial drawbacks when attempting to reliably identify modest allelic differences (<2.5-fold).