These data indicate that the mutations do not have a substantial dominant-negative effect on cellular translation in the stapled ribosome, consistent with the large subunit of O-ribo(h44H101) being functionally insulated from the endogenous small subunit.
A L'Olivier's range of vinegars made with fruit pulp, including mango, tomato, pimiento, cassis and fig, are rich and substantial without being dominant, and make some of the best dressings I have tasted.
Although ICERs were more sensitive to cost discounting than effectiveness discounting, there was no substantial change in dominant cost-effectiveness.
In one-way sensitivity analysis (Table 4), varying recurrence rates between 95% CIs did not have any substantial impact on dominant cost-effectiveness.
Thus, we conclude that the contribution of XGD to the observed variance of relative evolutionary rates is substantial but not dominant.
He emphasizes that the earlier self is a "higher self," "rational and autonomous," and that her interests are associated with the dominant, more substantial and lengthy part of life, integrated — through strong prudential connections among its various stages — into one unified life-segment.
Livestock and butter sales also make a substantial complement to the dominant crop sales.
At the resonance frequency of the dominant mode, substantial reductions in sound pressure level are readily achieved throughout the enclosure.
The study shows that market attributes have a substantial bearing on the dominant modes of fulfillment, on customer-centric performance metrics and on automaker costs.
The Integral Resonant Control (IRC) utilizes this unique property to add substantial damping to the dominant resonant mode by the use of a simple integrator implemented in closed loop.
Recent studies have provided substantial evidence that a dominant genetic variant has emerged across much, if not all, of North America (2 – 4 ).
