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Modern web map services are sophisticated systems, where their installation and configuration require substantial domain knowledge and experience as well as considerable efforts from the administrators.
One may worry, again, about whether there is an interesting or fruitful normative story to be told (rather than a merely banal descriptive sociology), but it suffices for the analogy with Quine that there remains some substantial domain of cases where the foundational program can not be carried out, so that the case for replacement remains intact.
That is, the formal structure of a substantial domain of knowledge may not be evident when knowledge is accumulated by piecemeal sampling.
As domain domain movements usually occur on a nanosecond scale (Haran et al, 1992; Wang et al, 2006), the extension of the simulation to 10 ns should be long enough to detect at least the beginning of substantial domain movements.
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Becker muscular dystrophy, a condition that typically arises from dystrophin gene lesions that do not disrupt the reading frame, clearly indicates that substantial domains of the dystrophin protein are not essential.
The low dimensionality of this semantic map indicates that, although thousands of distinct categories of meanings are conceivable, only very few apply to all contexts without a substantial domain-specific alteration of their semantic content.
The spectra also contain additional intense resonances consistent with substantial, domain-specific unfolding.
Health professionals involved with interRAI assessments can be reassured that they cover substantial domains of the ICF, particularly in the domains of Activities/Participation and Body Function.
We chose to not include the middle category "relevant" in the categorization of "substantial" domains because based on the methods we used for generating this list of 34 domains, we expected all of the domains to be relevant.
Whilst some indels appear to be species-specific, we observe four substantial domains (length greater than 30 nucleotides, with a total of 469 nucleotides) that are conserved in all tephritid species but absent in all Drosophila species (see Additional File 6, Figure S3).
The GCPRs have seven transmembrane domains, substantial intracellular domains between the fifth and sixth transmembrane segment, an extracellular N-terminal and an intracellular C-terminal domain (Strader et al., 1994).
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