Sentence examples for substantial discontinuation from inspiring English sources

Substantial discontinuation of use of Mirena was noted and makes interpretation of findings for this treatment difficult.

The long noninterventional follow-up period was associated with a substantial discontinuation rate (54 of 108 eligible subjects participated in the follow-up visit).

Another study, in a commercial health plan population during the period of 2006 2008, reported substantial discontinuation, restarting, and switching among new users of various anti-osteoporosis medications [ 29].

Overall a substantial proportion of treatment discontinuation in the first few months is due to adverse effects of medication [ 1].

Substantial increases in medication discontinuation and notable differences between blacks and whites occurred by the end of the first six months of therapy (34% blacks vs. 25% whites).

Finally, eight patients had PD; in five there was radiologic PD and in three patients there was substantial clinical deterioration, meriting discontinuation of therapy.

One major limitation that affected all the trials stemmed from discontinuations and substantial losses to follow-up for measurement of BMD outcomes at final time-points.

Premature TB treatment discontinuation remains a substantial problem in 11 districts in Bihar especially among individuals who repeatedly seek TB care.

While the agents are associated with slightly improved survival outcomes when compared to tamoxifen alone, bone and musculoskeletal side effects are substantial and often lead to discontinuation of therapy.

The substantial rates of lithium and valproate discontinuation observed here (median time to discontinuation of approximately 90 days) may not be particularly unusual.

Although the latter two side effects are usually mild, they are persistent, can lead to treatment discontinuation and have a substantial negative impact on a patient's quality of life.