These adverse symptoms can cause substantial discomfort, functional loss and distress to patients; they limit treatment tolerability, and can persist indefinitely in post-treatment survivorship [1].
Also at week 12, patients self-reported ocular discomfort on a scale ranging from 0 ("no discomfort") to 9 ("substantial discomfort").
Given that urethral complications would probably result in substantial discomfort and stay in hospital, we assumed that the quality of life associated with this health state would be similar to that experienced by patients with multidrug resistant UTI.
The application of regional chemotherapy to the liver requires arterial catheter placement, which is frequently associated with catheter complications, such as infections, hematomas, or thromboses, meaning in-hospital stays for several days or even weeks and substantial discomfort for the patient.
Other types of conditions where IHC interventions might be useful are likely to be those where CM use is high, such as the for the treatment of health problems where there is unmet need and conventional care has not been able to help; that have an unpredictable course and prognosis; and that are associated with substantial pain, discomfort, or side effects from prescription drug medicine [ 4, 55].
As a result, these rehabilitations are usually associated with substantial clinical time, patient discomfort, and high treatment cost.
We try to quantify objectively the effects of parallax, depth and motion, exporting the common situations in which discomfort is substantial, from opinions of observers derived from empirical and subjective tests.
Any inflammation in that little area inside the wrist -- the carpal tunnel -- (whether it comes from overuse, hereditary factors, arthritis or a fracture) can cause extreme discomfort and substantial disability.
Given the importance of this condition, often associated with substantial patient suffering and discomfort, gaps in knowledge about its prognosis, and documented underreporting and shortcomings of ICD-10-based algorithms, there is a need for establishing systematic research databases with universal and prospective registration of ONJ cases.
As rated on the eVAAS, the healthy volunteers experienced a significant sense of "fear" or "discomfort" while reporting substantial panic symptomatology on the PSL.
The rationale driving this paper is that the most common cause of pain in older people [ 7] may be being overlooked as it is rarely implicated as a cause of death, despite the potential for musculoskeletal disease to be a substantial cause of pain and discomfort in the dying person.
