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Both approaches have contributed to the discovery of new drugs despite suffering from substantial disadvantages of high cost and time.
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But PMCs have a substantial disadvantage of low conductivity and therefore low Electromagnetic (EM) Shielding.
The most substantial disadvantage of that scheme is reasoned in its difficult applicability at slaughter line especially under field conditions.
Until recently a substantial disadvantage of the RAPD method was the absence of software for performing resampling tests (bootstrapping, jackknifing), and therefore the impossibility to assess the reliability of obtained trees.
However, most of these LC-MS/MS methods suffer from substantial disadvantages, which include low throughput [ 22], lack of full validation [ 10, 24], or incomplete analytical coverage (e.g., sphingomyelins) [ 25].
From the nowadays viewpoint, the conventional types of polarization have substantial disadvantages.
Okin and others demonstrate, for example, that women have substantial disadvantages in competing in the market because of childrearing responsibilities which are not equally shared with men.
Immigrants experience substantial disadvantages in employment in the host country.
Peripheral nerve blocks using "blind" or nerve stimulator techniques have substantial disadvantages.
They currently comprise 2.5% of the Australian population [ 1] and experience substantial disadvantage evident on a range of health and socio-economic indicators [ 2].
The data reveals that immigrant students suffer a substantial disadvantage with respect to natives in terms of their family background.
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