Sentence examples for substantial difficulties with from inspiring English sources

Participants encountered substantial difficulties with the inflexibility of the diagnostic equipment.

He complained that there were "substantial difficulties" with the current budget that would make it more difficult to cope with the anticipated effects of a slowing economy.

Countries are classified as LDCs partly because they score so poorly in terms of human assets, and such states are likely to have substantial difficulties with technological upgrading.Many African states have enjoyed short-lived growth "spells" driven by booming commodity prices.

During piloting of the questionnaires in the 2007 survey, we identified substantial difficulties with subjects recalling events over specified periods of time.

Table 2 shows the proportions of children with a DDA-defined disability reported as experiencing substantial difficulties with specific areas of daily living.

These findings suggest that pulmonary NTM infections pose substantial difficulties with regard to clinical management of NTM and MDR-TB diseases in China.

It is therefore little wonder that perioperative care providers may have substantial difficulty with do-not-resuscitate (DNR) orders.

All (four) patients in the 2100-mg cohadt had substantial difficulty with the capsule load (seven capsules of 300 mg BID).

At 2100 mg BID grade 3 anorexia and a combination of grade 3 anorexia and fatigue yielded protocol-defined DLT in two patients, but because of substantial difficulty with capsule intake experienced by all other patients at this dose, capsule load at 2100 mg BID was considered dose limiting as well, albeit not defined by protocol.

Substantial difficulties remain with performing WGS on bacterial samples on a routine basis or even just during outbreaks.

Discovery of insertions and deletions smaller than 20 bp is a prevalent part of variant discovery pipelines (GATK, [ 38]) and poses no further challenges to the user, while discovery of indels greater than 20 bp still comes with substantial difficulties.