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Substantial difficulties due to nonidentical relative degrees and directed interaction graphs are surmounted in this result.
The only 2 papers that did use CT scanning (Yian et al. 2005 and Arnold et al. 2011) both described substantial difficulties due to metal artifacts.
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Substantial difficulties arise in epigenetic regulation, including with inhibition, due to the context-dependent nature of effects, linked, at least in higher organisms, to redundancy and adaptation.
Nevertheless, we do not believe this kind of recall to be a major threat to validity because in our experience most patients have substantial difficulties remembering even important activities and interactions from the admission phase, which is likely due in part to how overwhelming rehabilitation appears to be for patients at the start of rehabilitation.
Distortions due to reverberation have a direct impact on the modulation spectrum, and they also cause substantial difficulties for human listeners [15],[15].
"There are substantial difficulties in prosecuting cases committed in war zones," the official said.
Their preparation can be achieved without substantial difficulties.
This can cause substantial difficulties in obtaining results which are easily presentable.
Participants encountered substantial difficulties with the inflexibility of the diagnostic equipment.
The membrane itself may play a role but creates substantial difficulties for structural studies.
For some applications, there are substantial difficulties involved, such as the slow convergence of GMRES (particularly for free boundary and moving interface problems), and the inconvenience in finding a preconditioner (due to the situation that only the products of A and vectors are available).
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