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The phrase 'substantial differences in' is correct and usable in written English.
You can use it when referring to significant differences between two or more subjects. For example, "The study showed substantial differences in student test scores based on gender."
Exact(60)
Comparative analyses of genomes have already demonstrated substantial differences in the kinomes of different eukaryotes.
Furthermore, we found no substantial differences in reconstruction time and speed between different IR levels.
The data show substantial differences in the OOPE level between households with different characteristics.
There are substantial differences in the amount of research concerned with different disorders.
No substantial differences in reconstruction time and speed were found between different IR levels.
For example, there are substantial differences in Hempstead and Great Neck.
But a glance at the strengths of these three reveals commonalities of understanding if substantial differences in execution.
There are substantial differences in conditional rates.
However, one can imagine there being substantial differences in concentration.
However, there were substantial differences in species composition.
These reports show substantial differences in their results.
More suggestions(17)
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large differences in
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great differences in
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massive differences in
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many differences in
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com