Sentence examples for substantial defects in from inspiring English sources

I wish I could brag about them over beers, but due to substantial defects in my personality, both failed to evolve into anything lasting longer than a few hours.

Since DNKv4 motoneurons displayed substantial defects in repetitive firing, we investigated whether these defects would be translated to behaviors that involve repetitive or rhythmic movement.

With the exception of Nef M20, all of the mutant proteins with known defects in the down-regulation of MHC-I in human cells had substantial defects in our in vitro binding assays using purified recombinant proteins.

We demonstrated substantial defects in Ca2+ influx in psoriatic keratinocytes in response to high extracellular Ca2+ levels, associated with a downregulation of all TRPC channels investigated, including TRPC6 channels.

The small size of dcko limb buds was not due to any substantial defects in expression of Fgf8 in the apical ectodermal ridge or Sonic hedgehog (Shh) in the zone of polarizing activity (Fig. 7IVA H).

Vav1-deficient mice exhibit substantial defects in T cell development, marked by a block at the DN3 stage and dramatically reduced activities of ERKs and PLC- γ1[17], [18], critical downstream mediators of Vav signaling in response to TCR stimulation.

The spt16-m allele contains two amino acids substitution (K692AR693A) in its tandem pleckstrin homology (PH) domain and displays a subtle defect in transcription initiation but a substantial defect in DNA replication-coupled nucleosome assembly (Yang et al., 2016).

We also monitored possible effects of A2ML MO injection on blood vessel formation in the liver by inspecting fliGFP transgenic animals, and found no substantial defect in blood vessel formation (Fig. S2A B).

On the other hand, Notch1 receptors lacking the S1 loop exhibit a substantial defect in transport to the cell surface, with steady state cell-surface levels reduced by 5 10-fold, even though there are comparable levels of overall expression.

Given our failure to find a substantial defect in ErbB2 transcription or protein degradation rates, we suspected this higher molecular weight form may represent ubiquitinated ErbB2 that accumulates upon POH1 knockdown and may be less easily detectable by western blotting due to its heterologous molecular weight.

We looked at ribosome biogenesis, and were inspired when we noticed that there is a substantial defect in rRNA transcription.