Sentence examples for substantial decrease in activity from inspiring English sources

This mutant also showed a substantial decrease in activity towards the MH-1 peptide similar to that observed for the eEF2K[T348A] mutant.

Although such a decrease was supported by the observation that overall activity in constant light (LL) and DD was similar, we noticed a substantial decrease in activity in mutants under DD relative to controls, precluding a conclusion about masking from these data alone.

In earlier studies, quantification of DGAT activity during seed maturation in B. napus indicated that enzyme activity was maximal during the rapid phase of oil accumulation with a substantial decrease in activity occurring as oil levels reached a plateau [ 67, 68].

Lovastatin was the statin used in this study because it is readily available as a generic drug and is lipophilic, a feature of statins that have shown efficacy in recent breast cancer studies[ 25, 26] MTT assays showed that lovastatin exposure triggered a substantial decrease in activity in all cell lines with MTT50 values that ranged from approximately 2 to 40 μM.

Septic animals displayed clinical signs of disease including a substantial decrease in activity and accumulation of peritoneal exudate as well as laboratory signs of systemic inflammation paralleled by multiple organ dysfunction (Table 1), including hepatocellular injury, increased markers of cholestasis and a reduced cumulative bile flow (Table 2).

Patients with low back pain and sciatica report fear of movement and substantial decreases in activity levels [ 39], and recently, patients with lumbar spinal stenosis reported significantly lower activity levels than both control subjects and patients with either knee or hip osteoarthritis [ 40].

Long time scale processes were observed to result in cation exchange properties accompanied by a substantial decrease in redox activity and/or CV currents of the polypyrrole electrode.

By the end of 5th laundry cycle there was substantial decrease in its activity to 46 and 55 % respectively for E. coli and S. aureus.

Activation of the mutant RIα allele in hepatocytes using Alb-cre transgenic mice results in a substantial decrease in PKA activity only in the liver, demonstrating that the RIαB mice can be used to elicit a dominant negative PKA effect in a cell-specific manner in vivo.

A substantial decrease in TrxR activity was observed already after 4 h in the H1299-His175 cells.

We have also recently shown a substantial decrease in p56lck activity in T lymphocytes of healthy elderly subjects [ 15].