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NASH is characterized by a fatty liver, hepatic inflammation, and substantial death of hepatocytes.
Although treatment with a MEK/ERK inhibitor also led to increased Bim protein levels, neither MEK/ERK nor PI3K inhibition alone or in combination induced substantial death of cells expressing mutant JAK2.
Similar(57)
Being especially vulnerable to disease to begin with and highly localized from the start, a substantial death toll of the elderly is almost guaranteed once a disease enters such a facility.
To avoid confounding effects of the substantial death induction seen at 48 h, CTR1 levels were assessed after 24 h of chemotherapy +/− DL-TBOA.
GO provoked the substantial cell death of E14.5 fetal liver cells via apoptosis, as shown in Figure 5A, the percentages of Q4 (early apoptosis) plus Q2 (late apoptosis) were significantly increased in GO-treated cells (at 20 μg/ml, P < 0.05) compared to the control cells.
The jury said Propulsid, which was removed from the market in 2000 after being linked to 70 deaths, was not a substantial factor in the death of John Calvert of Napa, Calif.
The results from T-cell blasts mirrored our findings in thymocytes, demonstrating lack of substantial cell death in the absence of p53 and a failure of Chk1 inhibition to sensitize these cells to IR.
And yet the diplomatic failures of that fateful summer led to the great slaughter of the trenches, the death of a substantial portion of the younger generation, and a virtual nervous breakdown of authority in politics and culture.
They are associated with widespread death of poultry, substantial economic loss to farmers, and reported infections of more than 300 people with a mortality rate of 60% [1].
13 Placing too large of a volume with each pass will result in the death of a substantial portion of the fat cells and loss of volume.
In contrast, bcr/abl p210T315I -expressing Stat5 fl/fl Mx1Cre cells showed substantial cell death upon loss of Stat5 (Fig 7D, right panels).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com