Given the substantial data suggesting that cytokines markedly influence neurotransmission and neuronal survival, the present findings support an involvement of environmental contaminants in the development of neurological or psychiatric disturbances.
Only three prior studies, including our initial reports, evaluated results by tumor hormone receptor status [ 13- 15], a particularly important consideration given the substantial data suggesting heterogeneity in risk factor associations by tumor hormone receptor status [ 16- 19].
Substantial recent data suggest that a small PC with pure Gleason 3 + 3 does not pose a significant threat to a man's life allowing deferment of treatment and inclusion in an active surveillance program as a valid option [22, 23].
Animal model studies and substantial clinical data suggest that blood-brain barrier breakdown frequently follows head trauma [ 24].
Substantial experimental data suggest that the dose response relationship for health effects of formaldehyde is nonlinear (Nielsen and Wolkoff 2010).
Moreover, substantial experimental data suggest that the coagulation system is implicated in multiple cancer pathways, including tumor proliferation, angiogenesis, apoptosis, and metastasis 9, 10.
4, 5 Finally, despite early animal studies indicating an association between statins and increased risk of tumors, 6 substantial experimental data suggest that statins may in fact have antiproliferative and proapoptotic effects.
The potential impact of these observations is substantial because epidemiologic data suggest that a reduction in SBP of 20 mmHg or DBP of 10 mmHg has the potential to reduce adverse events by as much as 50%% [ 6].
However, there are substantial modeling data suggesting that the majority of the tumor, or tumor bulk, has a uniformly high pressure.
