Copy number change of the 19q12 locus showed a degree of tumor specificity, in that the amplification was not seen in 10 other tumor types for which substantial data was available, including small cell lung, hepatocellular, colorectal and prostate cancer (data not shown).
Statistical models were used to estimate the degree of synergism, which could be determined with reasonable precision because substantial data were available.
The weight of air pollution epidemiology necessarily rests largely on estimates of exposure derived from monitoring data mandated by air quality regulations; thus, substantial data are available for only a few pollutants and pollutant classes.
The activins A and B, members of the Transforming Growth Factor β family of proteins, and their binding protein, follistatin, have recently been shown to be important regulators of inflammation and fibrosis but no substantial data are available concerning their roles in ARF.
Evidence derived from a small number of randomized trials, as well as substantial observational data, is consistent in supporting the benefits of standard HF therapies, and particularly ACE inhibitors and β-blockers, in elderly patients (Arnold et al 2006).
Second, the absence of non-trivial timing signatures for significant parts of both datasets may pose a substantial problem if data is used for detailed timing (or causal) analysis.
Subsequent per-protocol analysis may be needed in case a substantial number of data is lost during follow-up.
For accurate long-term prediction of prescribed burning, substantial field data are still needed to identify productivity recovery pattern, carbon allocation after burning, and long-term effect of burning on productivity.
Non-significant variables and variables with substantial missing data were eliminated with 89.1% of the sample retained for analysis.
Substantial primary data were also collected using questionnaires developed by the consultants and checked by UNICEF, the sponsors and the Zambia Community Schools Secretariat (ZCSS), representing the Ministry of Education MOEE).
