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Substantial data has demonstrated that radiation can cause gross malformations, growth retardation, and central nervous system abnormalities in the fetus (Straume, Blattnig, & Zeitlin, 2010).
Substantial data has shown that the lectican group of chondroitin sulfate proteoglycans are involved in inhibition of axonal plasticity in response to injury in the central nervous system.
However, by now substantial data has accumulated that the peculiar properties of certain targeted mutations on the C57BL/6J background are not seen when the mutation is expressed on the background of other popular strains such as FVB/N or 129/Sv, or mixed (hybrid) mouse backgrounds, or even in the patient, whose disease was modeled in the mouse.
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Substantial data have shown the essential role of oxidative stress in the regulation of diverse cellular events [ 1, 2].
Substantial data have been generated during the last 5 years in experimental systems and human populations which shed light on the potential usefulness of biological markers in human cancer risk assessment.
Although H3K9me2 was originally described as a "silencing" mark due to its association with heterochromatin (Bannister et al. 2001), substantial data have accumulated to indicate that H3K9me2 can be present on expressed genes.
Substantial data have unraveled that tumors of oral cavity undergo accelerated repopulation in the 4th week of conventional radiotherapy and thus require higher doses to overcome this undesired effect [ 21].
However, a substantial quantity of data has been accrued to implicate chronic metabolic acidosis as an additional important factor [ 13].
Since then, substantial research data have accumulated for cadmium on chemistry in soils, additions to soils, uptake by plants, adverse effects on the soil biota and transfer through the food chain.
Substantial genotyping data have been produced from genome-wide association studies, which can be directly exploited for the CNV analysis.
Considerable progress toward a settlement, including a substantial transfer of client data, has been made.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com