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The control samples were carefully evaluated and patients having any evidence of prior hypertension or who did not complete a substantial course of bevacizumab were removed from the analysis.
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UK law on contempt is set out in the 1981 Contempt of Court Act, which applies to all publications that create "a substantial risk" the course of justice will be "seriously prejudiced".
Strict liability arises where a publication creates a substantial risk that the course of justice will be seriously impeded or prejudiced.
A helpful "Dramatis Personae" at the end of the book lists nearly 150 people, all of whom are given substantial treatment during the course of the narrative.
The environment itself provided a substantial challenge over the course of the tour: Katrina touched down days before the inaugural performance, on Sept. 12, 2005, and several planned appearances along the Gulf Coast were canceled.
But he alleged that the articles in the Mail and Mirror were "given particular prominence" and "clearly and in themselves gave rise to a substantial risk that the course of justice would be seriously impeded".
Under Britain's 1981 Contempt of Court Act, publishing material is an offence and potentially liable to a gag only if it poses "a substantial risk that the course of justice will be seriously impeded or prejudiced".
According to "Dollo's Law," many substantial changes during the course of evolution are irreversible.
Comorbid anxiety disorders are extremely prevalent in bipolar disorder (BD) and have substantial impact on the course of illness.
River flows also suffered a substantial decrease in the course of climate change and human interference, especially the overland flows (4/5 decrease) and the base flows (2/3 decrease).
HC-3 binding showed a substantial increase during the course of nicotine treatment and again, the effect was limited to the midbrain.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com