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(Hybrids like the Prius do that, but at a substantial cost premium).
Although these devices have the potential to improve patient outcomes, they are consistently introduced into the market at a substantial cost premium and before validation of their clinical benefit and cost-effectiveness through well-designed, prospective clinical studies.
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In this environment, retailers began to question Cloudy Bay's substantial price premium, he said.
Benefits of building green outweigh any potential cost premium.
The lawmakers noted those potential benefits for patients, but they said the expensive medication could impose substantial costs on taxpayer-funded Medicaid programs and lead to premium increases for those with employer or individual health coverage.
The Pentagon cited "substantial" costs.
One of their substantial costs is picking.
Priceline has also benefited from substantial cost-cutting.
Further substantial costs are special education expenses.
All of these decisions had very substantial costs.
They must pay a substantial insurance premium of 1.75percentt of the loan.
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