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Nevertheless, the computational effort to run these models remains a substantial constraint on their application.
It imposes, however, a substantial constraint: If we insist on including down markets in our comparison, we eliminate many of todays hot investment letters and mutual funds.
Defenders of Kant's ethics argue that it represents a substantial constraint: to avoid all those ways of thinking and acting that cannot be followed by all.
In many of these states health conditions are particularly difficult and the loss of skilled health workers is a substantial constraint to effective health care delivery.
This indicates that the majority of methylation patterns in genome regions are not originated from stochastic methylation events but rather under substantial constraint.
This finding shows that form-selective motion sensitivity in the STS can be explained in terms of modulation of gain control on information flow in the motion pathway, and provides a substantial constraint for theories of the perception of faces and biological motion.
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For example, there are substantial constraints on what could be considered courage.
He argued there were substantial constraints on individual schools changing - such as a large majority of schools planning to retain national arrangements for pay and conditions.
If this possibility is true, then there are substantial constraints on crime or places that prevent crime from behaving like other phenomena.
Substantial constraints are apparent across each of the six key health-systems components of health financing, governance, health workforce, health information, medical products and technologies, and health-service delivery.
Even if there are substantial constraints on what story will be adequate, and these constraints are not due merely to facts about us or our choices, there may still be some scope for the story to be artificial to a small degree, for some points of detail may be left underdetermined by the constraints.
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