Sentence examples for substantial conformational changes from inspiring English sources
It is tempting to propose the substantial conformational changes of the ARP module could play a role in modulating the conformation of the Snf2 ATPase domain, thus controlling the efficiency of SWI/SNF remodeling, which is consistent with previous functional and structural observations on the regulatory role of ARP module (Clapier et al., 2016; Xia et al., 2016).
GK is known to undergo substantial conformational changes upon glucose binding.
Here, we show by intramolecular Förster resonance energy transfer spectroscopy that ligand binding induces substantial conformational changes in the ectodomain of ifnar1 (ifnar1-EC).
Co-folding with FliFC induces substantial conformational changes in FliGN and suggests that FliF and FliG have the same stoichiometry within the rotor.
Comparisons between inactive- and active-state opioid receptor structures reveal substantial conformational changes in the binding pocket and intracellular and extracellular regions.
Reconstructions of the apo, ATP, and ADP states identify that Rvb1/2 undergoes substantial conformational changes that include a twist in the insertion-domain position and a corresponding rotation of the AAA+ ring.
Herein, modeling studies with dirlotapide, a CYP3A4 substrate, indicated that a substantial conformational change of CYP3A4 was necessary to accommodate it within the active site cavity, which is in good agreement with a new published CYP3A4 ritonavir co-crystal structure.
In-silico analysis revealed that Tyr176 and Ser473 are located in regions with increased conformational flexibility and phosphorylation at Tyr176 is likely to induce substantial conformational change and thus affect the loop harboring Ser473 (Fig. S3).
Therefore, the large variations in the P r) indicate a substantial conformational change in the RRE.
Rather, the substantial conformational change of cohesin in preparation for loading is likely to be rate limiting.
These data are indicative of a substantial conformational change at the TM IV/V interface during 5HT2c receptor activation.
