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There has been substantial concern that aspen has been declining in the western US, but trends of aspen persistence vary both geographically and temporally.
In the other countries there is substantial concern that the increased use of asbestos may result in an increase in the number of cases of MM for many decades.
Services have been established, but there is now a substantial concern that significant numbers of services are failing to attain the standards set for multi-factorial programmes by NICE.
In the United States, a revised drinking water standard for arsenic of 10 micrograms per liter (μg/L) is set to take effect in January 2006, but there is substantial concern that this level is still too high for public safety.
The presence of Hy's Law cases in a pre-approval clinical trial database raises substantial concern that post-marketing liver failure cases associated with the study drug are likely to occur, assuming that the incidence and prognostic implications of these events can be projected into a large treatment population.
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We will also expect any appeals process to thoroughly and transparently address the substantial concerns that have been raised in these tribunals".
Both reviewers also raised some substantial concerns that will need to be addressed by additional experiments.
However, each reviewer has substantial concerns that would need to be addressed before publication of the paper could be considered.
Both reviewers were enthusiastic about many aspects of the study, but both raised substantial concerns that are largely complementary to one another.
While there was in principle broad enthusiasm for the work among the reviewers, there were several substantial concerns that preclude acceptance of the work in its current form.
However, the reviewers also expressed substantial concerns that should be addressed by additional experiments and/or by discussion before publication is recommended.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com