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There is therefore substantial concern about abnormalities in cloned humans.
Taken together, the scientific literature provides adequate biological plausibility and raises substantial concern about the potential for PBDE-related developmental neurotoxicity in humans.
Although there is substantial concern about negative attitudes to mental illness, little is known about the stigma associated with Generalised Anxiety Disorder (GAD) or its measurement.
As-needed [ 103] and episodic high-dose [ 104] ICS have also been studied, but there is substantial concern about the risk of side-effects with their over-use, so regular low-dose ICS should be tried first.
Given the substantial concern about the broad under-diagnosis and under-management of depression in primary care [ 1], most primary care treatment intervention strategies have aimed to improve outcomes through better detection and by increasing the likelihood of guideline concordant treatment in the acute phase [ 2].
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Third, the board has substantial concerns about the underfunded status of United's pension plan.
They listed nine alleged flaws by Merseyside police in their investigation into the death and expressed their "real and substantial concerns about the safety of Gilfoyle's conviction".
The administration has committed to spend more money for that purpose, but "there remain a few substantial concerns about the adequacy of the proposed budget," the memo said.
Mark Lever, the charity's chief executive, said: "We have substantial concerns about the introduction of a face-to-face assessment for the new benefit.
In addition, there are substantial concerns about political stability in Bahrain and Saudi Arabia's oil-rich eastern province, and potentially even in Kuwait and Jordan – all areas with substantial Shia or other restless populations.
"For over two decades, there have been substantial concerns about working conditions, particularly worker safety," said Aron Cramer, the president and chief executive of B.S.R., a consulting firm that works with businesses on social-responsibility issues.
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