Peripheral nerve injuries represent a substantial clinical problem with insufficient or unsatisfactory treatment options.
However, many ErbB2-positive cancers exhibit intrinsic resistance, and the widespread development of acquired resistance to ErbB-targeted agents remains a substantial clinical problem.
This review will summarize the most recent research designed to address this substantial clinical problem and provide clinicians with relevant background for understanding some of the potential molecular mechanisms for resistance to targeted therapies in the treatment of patients with breast cancer.
CONCLUSION: LRR after mastectomy is not only a substantial clinical problem, but has a significant impact on the outcome of patients with T1 or T2 primary tumor and 1-3 positive axillary nodes.
Youth onset of type 2 diabetes continues to increase worldwide (1), and pregnancy in women with type 2 diabetes is a substantial clinical problem (2).
iDILI represents a substantial clinical problem as it can arise from drugs that are very commonly prescribed and thus represents a widespread issue.
Others have recognized acute and chronic pain in this patient population as a substantial clinical problem [ 29- 31], while others have not [ 7, 8].
However, because HA rotavirus infection remains a substantial clinical problem ≈20 years after publication of a seminal study on the subject (22 ), even stringent infection control precautions are likely to be insufficient to greatly reduce the problem.
Of general note, resistance to chemotherapy, despite initial limited response in some cases, is a substantial clinical problem accounting for treatment failure in more than 90% of patients with metastatic disease, the inevitable outcome being death (Longley and Johnston, 2005).
Second, as interindividual variability in the response to drugs remains a substantial clinical problem, a major objective of pharmacogenomic research is to decrease adverse responses to therapy through determination of adequate therapeutic targets and genetic polymorphisms that alter drug specificity, metabolism, and toxicity [ 11].
