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As such, there is a substantial clinical need for replacements of damaged cartilage.
Substantial clinical need has been established for an adjunct to existing diagnostic tools for differentiating PD from ET, and DLB from AD. Examiner expertise affects diagnostic accuracy, with subspecialists having the highest accuracy, followed by general neurologists; primary care physicians tend to have the lowest.
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However, there is a substantial unmet clinical need with regards to postmortem investigation of early gestation fetal loss for parents for whom standard autopsy is either not available or not acceptable.
A recent assessment of asthma across Europe (Brussels Declaration) has identified substantial unmet clinical need which, in the 10% of patients with severe disease, accounts for approx. 50% of the health costs [ 1].
Considering that long-term therapy is required in the adjuvant setting or as a part of cancer prevention strategies, candidate prevention or treatment medications will need substantial clinical safety data to be considered for study.
Substantial clinical illness among preschool children argues the need for them to be enrolled in vaccination programs.
Deferred treatment initiation prioritises those patients in greatest clinical need of ART, but still excludes substantial numbers of patients at risk.
In view of these risks, deferring surgery or downstaging the surgical procedure needed to treat GCTB may offer substantial clinical benefits to patients.
62 In addition, there is substantial previous evidence of underutilization of joint procedures by minorities unrelated to clinical need.
There is a need for quantitative Canadian research in GMV broadly and we target the substantial clinical problem diabetes in older people.
There has to be clinical need".
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