Sentence examples for substantial clinical data from inspiring English sources
Animal model studies and substantial clinical data suggest that blood-brain barrier breakdown frequently follows head trauma [ 24].
It is therefore reasonable to expect that the sensitivity and specificity of the alpha-defensin test in this study should approximate these previous publications that included substantial clinical data.
Despite substantial clinical data demonstrating the superiority of platinum-based regimens vs non-platinum regimens, the non-inferiority of carboplatin over cisplatin, and the benefit of paclitaxel combined with platinum-based regimens, the molecular basis to OVCA sensitivity to these drugs remains to be fully characterised.
Although meeting the regulatory criteria to approve biosimilar medication for a given indication on the basis of comparative studies with the reference product may be sufficient to support switching, substitution of insulins at the pharmacy level will require more substantial clinical data.
Considering that long-term therapy is required in the adjuvant setting or as a part of cancer prevention strategies, candidate prevention or treatment medications will need substantial clinical safety data to be considered for study.
On the other hand there is vast experience with and substantial clinical trial data for so-called selective digestive tract decolonization (SDD) regimens in intensive care patients and in neutropenic cancer patients in whom preventive treatment with nonabsorbable drugs like colistin plus tobramycin can decrease the risk of infection due to gram-negative enteric bacteria [ 6].
Even if the intervention proves not to be beneficial substantial additional clinical data about the natural history of AVFs, use of CVCs and long term outcomes of AVF surgery will inform clinical practice.
A particular focus is on gastric tonometry, the only technology that has accumulated a substantial body of clinical data.
▪ Although the use of structured electronic databases is widespread, a substantial amount of clinical data used in research predates this.
There is a substantial amount of clinical data showing the relationship between diabetes and atherosclerosis and its clinical complications (1, 2).
Substantial preclinical and clinical data suggest that pathogenic B cells contribute to SLE pathogenesis by complex mechanisms including autoantibody production, antigen presentation, and cytokine generation (5).
