On the flip side, the identification of genetic variants in transporter genes with protective or beneficial effects provides substantial therapeutic targets in clinical application.
Nevertheless, further experimental studies are required to elucidate the releasing mechanism in specific to these five miRNAs, although this may have no substantial influence on the clinical application for GNCA diagnosis as biomarkers.
Finally, our results are mainly biostatistically based but the clinical application is substantial.
A multimodality therapeutic regimen, which included medications as well as cleaning of the home, integrated pest management, and professional application of chemical controls, resulted in substantial clinical improvement.
Despite a substantial body of evidence showing the benefits of exercise, its clinical application is still underutilised.
The substantial beneficial effect of LBP when administered at later stage has an important impact for clinical application.
Our finding of deleterious effect of LBP administered at early period of spinal cord injury, so that its application should be avoided, and the substantial beneficial effect of LBP when administered at later stage has an important impact for clinical application.
Its clinical application remains limited mainly to the treatment of life-threatening diseases because of substantial toxicities associated with currently available BMT regimens.
Despite substantial response rates, formidable side effect usually developed in a great proportion of patients, deterring the clinical application of these regimens in far advanced HCC.
Take, for example, a recent study that concluded that chemotherapy followed by tamoxifen promises substantial clinical benefit for postmenopausal women with ER negative, lymph node-negative breast cancer [ 27] through post hoc application subgroup analysis.
