Sentence examples for substantial changes had from inspiring English sources

But as the engineering team got deeper into the project they discovered that substantial changes had to be made in the LR2's underpinnings.

Frequent routine monitoring in diabetic control patients enabled us to compare laboratory data at inclusion and 2 years later, confirming that no substantial changes had occurred during the course of the study.

The pieces have been lightly edited, he tells us, and no substantial changes have been made.

The new concept will honor the old Jeffrey's, though substantial changes have been made.

One is left with the assurance that, despite an eventual scandal, no substantial changes have been made where it matters.

This has been a genuine exercise and it is clear from our response today that substantial changes have been made in the interests of patients".

In Colorado, eight bills that would result in substantial changes have been approved in at least one house of the Legislature.

Following the Loma Prieta earthquake, substantial changes have been made to seismic design provisions of the bridges.

In light of that development, substantial changes have been made in terms of policy in law enforcement.

During the last ten years, substantial changes have been noted in the epidemiology of influenza in pigs, particularly with reference to significant geographical variations in terms of the virus subtypes and their associated genotypes.

Substantial changes have been seen in population-level SPVL over time, and similarly large differences can be observed in the unstratified CD4+ progression rates between different time periods.