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This permissive 2% threshold was applied in narrowing the list of experimental candidates in order to retain those which have a substantial chance to be alternatively spliced.
As a low fractional excretion of urea apparently represents a low glomerular filtration, we hypothesized that a combination of fractional sodium and urea excretion would yield the optimal prediction of patients with a substantial chance to respond positively to attempts to restore glomerular filtration.
For the use of such definition in an adolescent population one has to be quite critical about this low threshold, because the counterpart of a low beta-error is a high alpha-error, or in clinical terms: with such a low threshold there is a substantial chance to give a diagnosis of personality disorder to an adolescent that doesn't have the disorder (false positive).
Given the high incidence of ED patients with uncomplicated sepsis who have a substantial chance to progress to severe sepsis [ 12], and the financial burden associated with severe sepsis [ 15, 16], it would be important to explore if a measure as simple as early administration of antibiotics decreases hospital LOS, and thereby contributes to a reduction in healthcare-related costs [ 17].
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'Endocrine response uncertain' is defined as some expression of hormone receptors either quantitatively low or qualitatively insufficient to indicate substantial chance for response to endocrine therapies alone.
"I have a plan, but I don't want to ― look, I have a very substantial chance of winning, make America great again," he continued.
When hiring rates are very depressed, workers who lose their jobs are unlikely to find work quickly, and thus face a substantial chance of becoming long-term unemployed.
Research has shown that, in commercially available supplementation products, there is a substantial chance of contamination with banned substances and/or different concentrations of ingredients to those listed on the supplement container (Geyer et al. 2004).
"There is a substantial chance that the U.S. economy is headed into a lost decade, similar to what Japan has experienced in the past 15 years, possibly with zero inflation instead of actual deflation," said Robert J. Gordon, of Northwestern University, who serves on the committee that determines the start and end dates of recessions.
Everyone knows it, but not many politicians or mainstream journalists are willing to talk about it, for fear of sounding conspiracy-minded: there is a substantial chance that the result of the 2004 presidential election will be suspect.
I have a substantial chance of winning.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com