Sentence examples for substantial challenges when from inspiring English sources

Because ideal systems with near perfect sensitivity and specificity do not currently exist, and may be very difficult to produce for use in the field, users of available systems are faced with substantial challenges when interpreting the results from diagnostic tests.

More than 1000 yrs of human intervention and the variety of land uses pose a substantial challenge when attempting to estimate sediment fluxes which is the first requirement to protect fragile wetlands.

However proteogenomics faces substantial challenge when applied to identify more complicated gene structural variations.

However, substantial challenges remain when a patient is required to use multiple inhaler types, multiple medications, and/or combinations of medications.

Somalia has not had a stable government since 1991, leading to substantial logistical and safety challenges when reporting in the region.

A decline in the willingness of members of the public to participate in research of this kind poses substantial challenges for researchers at a time when the demand for representative data on ageing populations is high.

When ILS is present, gene trees can differ from each other and from the species tree, presenting substantial challenges to phylogeny estimation methods (Degnan and Rosenberg, 2009; Edwards, 2009).

Both works posed distinct, substantial challenges to the players.

Like most cities of its size and age, New Rochelle faces substantial challenges.

Within those four little words, though, lie a number of substantial challenges.

There are three substantial challenges in quantitatively characterizing reservoir heterogeneity.