Sentence examples for substantial challenges such from inspiring English sources

However, substantial challenges such as high peak temperatures, power densities and area footprints of vertical interconnects in each layer cannot be ignored.

While the promise of next-generation sequencing technologies has become a reality, they also present substantial challenges such as in the mapping of short sequence reads to the genome, polymorphism detection, characterization of allele frequencies from population samples and data management.

There are substantial challenges in designing such a vehicle, which appears to have been one of the factors that drew Reitz towards the project.

As such, substantial challenges for bioinformatic analysis are posed.

Yet this complex approach presents substantial challenges for rare targets such as FGFR2 amplification.

Parents also perceive substantial challenges to reducing participation such as possible conflict within the family and lack of resources to support behaviours to replace EM use [ 22].

There is a substantial challenge facing views such as Reid's.

However, PACS implementation and adoption, like many other healthcare IT implementations [ 2], represents a major change in a healthcare organization and has proved to be a substantial challenge to many such healthcare organizations [ 3, 9].

The GCX lists companies that "have made substantial, forward-looking contributions to surmounting global challenges," such as climate change, drinking water, deforestation, biodiversity, poverty, and responsible governance, among others.

However, implementation of such systems may meet substantial challenges.

Such coverage variations impose substantial challenges for reliable CNV detection.