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There are substantial challenges facing humanity in the water and related sectors and purposeful integration of the disciplines, connected sectors and interest groups is now perceived as essential to address them.
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There is a substantial challenge facing views such as Reid's.
The fundamental choice is whether its trajectory will remain marked by inertia... and by ineffective policies that have produced the substantial development challenges facing the region; or whether prospects for an Arab renaissance, anchored in human development, will be actively pursued".
KPMG said a range of challenges facing the airline raised "substantial doubt about its ability to continue as a going concern," the auditors' report said.
The foraging challenges facing an animal are substantial.
The (apparently substantial) challenge now facing UK hospitals, is how will they meet their patients' demand for health education?
The unique challenges faced by women of color are substantial and, to some extent, structural.
With a staff of 25,000 and 1,000 buildings, the challenge facing Manchester city council is substantial.
Like most cities of its size and age, New Rochelle faces substantial challenges.
He faces substantial challenges: other sellers can threaten to kill him if he lures their customers away.
Both leaders' parties face substantial challenges in elections this fall, so they have to proceed carefully, mindful of the political dangers of negotiating sensitive measures in an election year.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com