Sentence examples for substantial challenge when from inspiring English sources

More than 1000 yrs of human intervention and the variety of land uses pose a substantial challenge when attempting to estimate sediment fluxes which is the first requirement to protect fragile wetlands.

However proteogenomics faces substantial challenge when applied to identify more complicated gene structural variations.

Because ideal systems with near perfect sensitivity and specificity do not currently exist, and may be very difficult to produce for use in the field, users of available systems are faced with substantial challenges when interpreting the results from diagnostic tests.

However, substantial challenges remain when a patient is required to use multiple inhaler types, multiple medications, and/or combinations of medications.

CONCLUSION: California surgeons and oncologists caring for breast cancer patients report substantial communication challenges when faced with a language barrier.

In addition, such complex mixtures offer a substantial challenge for reproducible synthesis when scaling the material from the milligrams needed for exploratory work to the kilograms required for clinical trials and drug productions.

A substantial challenge was to find a prudent method for designating when a gene is turned on.

Reflexive stress responses occur during emergencies (e.g., infection, starvation, dehydration, or shock), when the brain must respond to a substantial challenge to homeostasis by mobilizing the HPA axis.

As the EPA is learning with the 2011 Chevy Volt range-extended electric vehicle, however, it's a substantial challenge to provide useful information on a vehicle's fuel consumption when it depends so much on how it's used.

Hackett faces a substantial challenge.

For the school leaders involved, forging these partnerships presents a substantial challenge.