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Respecting a wide range of worldviews while increasing acceptance of biological evolution as the scientific explanation for the origin of species is a substantial challenge that may be difficult to achieve.
Another substantial challenge that must be faced soon is the shift in many countries from ANC-based surveillance to the use of Prevention of Mother To Child Transmission (PMTCT) datasets.
A substantial challenge that has limited investigation of nanotube behaviors in environmental settings is the lack of a method by which to quantify them in biological or environmental media.
Despite considerable effort, standard technical definitions have remained controversial and the widespread use of generally accepted testing protocols has proven to be a substantial challenge that is not yet resolved (Borgert et al. 2011b).
While impressive results in terms of the total number of identified proteins have been achieved, fully characterizing each identified protein remains a substantial challenge that has not been surmounted by collision induced dissociation (CID), electron capture dissociation (ECD), or electron transfer dissociation (ETD) methods.
The current practice of cell immunotherapy against cancer has encountered a substantial challenge, that is, targeted delivery of therapeutic cells to tumour sites is not favourably managed.
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But many economists are dubious that consumer spending and exports can keep growing robustly in the face of substantial challenges that are now entrenched in the United States and are gathering force in many other major economies.
Despite substantial challenges that may limit savings opportunities in traditional areas, energy savings have increased from year to year.
There still remain, however, substantial challenges that need to be overcome in order to achieve a large-area assembly in a simple, cost-effective, and reproducible manner.
The ARRS still faces substantial challenges that primarily relate to case management and the development of key performance indicators to ensure that service delivery is improved.
Despite the substantial challenges that need to be overcome for successful drug development, a plethora of novel therapeutic opportunities are indicated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com