Sentence examples for substantial challenge of from inspiring English sources

However, their analytical applications still remained a substantial challenge of relatively low ECL intensity.

In addition to the substantial challenge of determining the mechanisms underlying health effects from exposure to ambient air, it is important to recognize that not all of the potentially biologically active constituents of organic air contaminants have been isolated and identified.

Even if the negative aspects of leaving research don't deter me, I must consider the substantial challenges of essentially starting fresh in patent law.

However, the city continues to face substantial challenges of congestion, poverty, overpopulation and pollution.

Health in Europe is better than ever before, yet there remain substantial challenges of premature disease – with variations geographically, between social groups and for minorities – and care for an ageing population.

While such practice may have facilitated the initiation of Bedouin urbanization and was in line with government policy of mass resettlement, it also placed substantial challenges on the development of an urban society according to the western-ideals that informed urban planning.

The potential activation of multiple biological pathways and system-wide responses in vivo creates a substantial challenge to the understanding of stochastic mixtures containing a distribution of surface hydrophobicity.

Irrigation has led to significant groundwater depletion, which poses a substantial challenge to the sustainability of water resources in this basin.

Pesticides commonly occur in aquatic systems and pose a substantial challenge to the conservation of many taxa.

Aspects of complexes involving ankyrin repeats, including featureless putative binding face surfaces and large binding interfaces, can present a substantial challenge to the development of small molecule inhibitors.

The nature of the interaction between a miRNA and its target – incomplete and interrupted base pairing – creates a substantial challenge for the prediction of candidate miRNA targets.