Sentence examples for substantial challenge given from inspiring English sources

While epistatic fitnesses for each pair of loci could easily be incorporated into the model, the multiplication of terms to be learned would provide a substantial challenge given any but the largest data set.

CKD is a substantial public health challenge given its high prevalence and association with adverse outcomes, including cardiovascular disease (CVD) incidence and all-cause mortality [ 2, 3].

There is certainly a substantial challenge in big data investigations and intelligent data visualizations around giving meaning to complex statistics and databases.

Hence, given the small sizes of bacteria cells, identifying the in vivo structure of the Z-ring presents a substantial challenge.

Given the substantial challenges associated with characterizing and quantifying ENMs in soils and sediments, little research has been conducted to date on the homogeneity of ENMs in these media.

Given the substantial challenges for quantitative structure-based predictions of conformational exchange linebroadening effects, the degree of correlation between the predicted and observed linebroadening in the 80′s loop of FKBP12 suggests strongly that Gly transiently adopts a negative ϕ torsion angle when that residue is in a trans-peptide configuration.

Hackett faces a substantial challenge.

For the school leaders involved, forging these partnerships presents a substantial challenge.

The fact that Cox doesn't is hardly a substantial challenge to that statement.

Yesterday, Jordan was upbeat and eager to put his arms around a substantial challenge.

On the other hand, Kidd's jumper with 1.4 seconds left to play looked pretty substantial to me and presents a substantial challenge to Dumars and the Pistons.