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There is a substantial challenge facing views such as Reid's.
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There are substantial challenges facing humanity in the water and related sectors and purposeful integration of the disciplines, connected sectors and interest groups is now perceived as essential to address them.
The (apparently substantial) challenge now facing UK hospitals, is how will they meet their patients' demand for health education?
The fundamental choice is whether its trajectory will remain marked by inertia... and by ineffective policies that have produced the substantial development challenges facing the region; or whether prospects for an Arab renaissance, anchored in human development, will be actively pursued".
With a staff of 25,000 and 1,000 buildings, the challenge facing Manchester city council is substantial.
KPMG said a range of challenges facing the airline raised "substantial doubt about its ability to continue as a going concern," the auditors' report said.
The foraging challenges facing an animal are substantial.
However this technology is facing substantial challenge from the need to reduce costs and/or increase performance.
Another substantial challenge that must be faced soon is the shift in many countries from ANC-based surveillance to the use of Prevention of Mother To Child Transmission (PMTCT) datasets.
Hackett faces a substantial challenge.
Since the outcome measures of lung impairment have considerable test-to-test variability, potential new therapies face a substantial challenge.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com