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Reclaiming salt-affected soil in arid and semi-arid countries is currently considered a substantial challenge because of water supply deficiencies.
Selecting a course coordinator presented a substantial challenge, because the course crossed over traditional disciplinary boundaries.
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Bacteriophage taxonomic classification reflecting phylogeny presents substantial challenges because of genome mosaicism (Lawrence et al., 2002).
Mapping of the hydrolytic and synthetic subsites and elucidation of the mechanisms that ensure substrate specificity of each subsite pose substantial challenges, because the determinants may be overlapping.
Assembly of shotgun sequenced fragments in soybeans presents substantial challenges because of the duplicated nature of the genome (Shoemaker et al. 1996), many repeat sequences, and common domains of several gene families.
Hackett faces a substantial challenge.
A more substantial challenge arises from the fact that 126 years after his death, Wagner remains a polarizing figure because of his radical nationalism and anti-Semitism.
For the school leaders involved, forging these partnerships presents a substantial challenge.
The fact that Cox doesn't is hardly a substantial challenge to that statement.
Yesterday, Jordan was upbeat and eager to put his arms around a substantial challenge.
On the other hand, Kidd's jumper with 1.4 seconds left to play looked pretty substantial to me and presents a substantial challenge to Dumars and the Pistons.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com