Sentence examples for substantial cell type from inspiring English sources

These data show that substantial cell type specificity exists in the senescence mechanisms and regulators used, and that the mechanisms underlying replicative senescence in any given cell type cannot be assumed but must be characterized on a cell type by cell-type basis (Shay & Wright, 2005).

Genes that are predominantly expressed in cells of mesenchymal origin, such as Vimentin and Desmin, could not be detected or were only expressed at low levels (Table  2), which is in agreement with the substantial cell-type homogeneity of the samples used for this study.

Analyses have shown that cellularly complex targets lead to averaged gene expression profiles that lack substantial amounts of cell type specific information [ 23].

Since comparisons of the negative and positive ion survey scans showed no substantial differences between each cell type (data not shown), a more detailed investigation by ESI-MS-MS usion parent ion scanning of individual phospholipid classes by specific collision induced fragmentation was carried out [ 59].

Importantly, 4  μg ml 1 mTHPC-PDT caused no significant neuron death compared with untreated controls but was sufficient to elicit substantial cell death in the other cell types.

Although the prognostic value of each cell type was substantial, we aimed to establish a predictor derived from tumour biological characteristics in the belief that multiple parameters would reduce current experimental limitations and increase the accuracy of patient classification.

Gene expression based on cell type exhibited substantial changes between different cell populations (Supplementary Fig. 6A).

Peritumoural and intratumoural cell counts of each cell type showed substantial concordance, with Pearson's r varying from 0.434 (CD83) to 0.714 (CD3).

However, in a non-articular human cell type, a substantial role for NF-κB was demonstrated recently in the coordinate induction of COX-2 and mPGES-1 by IL-1β [ 63].

Hemocytes have long been investigated as part of the innate immune responses to systemic infection [ 64], but have recently received substantial interest as a model cell type to understand the regulation of cell migration in the context of an intact and immune competent organism.

We find substantial differences among cell types in broad modifications and bivalent promoters.