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There was also a substantial category of retroflexes (hereafter [R]), accounting for 13% of the total data.
This change could be positive if it strengthens attention to risky projects in the middle, as evaluations have recommended; but negative if it helps shift some high risk ones to the (new) substantial category, weakening their oversight.
The inter-operator reliability was also excellent for all but UR2 MD which still fell into the substantial category (Table 1).
Even so, the inter-operator reliability was excellent in all but one category, UR2 MD which fell into the substantial category.
A geospatial analysis of the substantial category reveals two main hotspots of European taurine introgression, whereas the moderate category shows a north to south decrease of European taurine introgression (r=0.82, P<0.0001; Figure 3b).
The variables were either recoded into sets of binary dummies with 'irrelevant', 'do not know' or a substantial category as the reference category, or treated as continuous variables when applicable (see also Table 1).
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The 123 introgressed calves, representing the moderate and substantial categories, are found within 12 sub-locations in the northern and central regions of the study area (Supplementary Table S1).
All other exposed subjects were then classified in the non-substantial category.
Consequently, whereas cumulative cotton dust exposure was about evenly divided between substantial and non-substantial levels in Study 1, in Study 2 the majority of exposure was in the non-substantial category.
Corresponding kappa values for woman based scoring were even higher, but agreement remained substantial (5-category: 0.65, 2-category: 0.77).
Notably, the perturbed genes did not overlap significantly with E2F4 bound genes, and inspection of the perturbed sets of genes revealed no substantial functional category enrichment (including cell cycle and proliferation), thereby suggesting that these perturbations are not directly caused by removal of E2F4.
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