Sentence examples for substantial bone marrow from inspiring English sources

The reason for these differences may be that patients with bone metastases are a more heterogeneous group including those with one or two bone metastases as well as patients with massive engagement and prerequisites of substantial bone marrow infiltration.

However, a detailed quantitative analysis of bone marrow edema in this cohort has recently reported that about a third of patients with substantial bone marrow edema still had minimal radiographic changes after 7.7 years of follow up [ 42].

The same "rescued" response following oral B[ a]P treatment was observed in the triple knockout Cyp1a1/1a2/1b1 mouse line, i.e. the absence of CYP1B1 in immune tissues is sufficient to avoid substantial bone marrow depression [ 113].

As the song says, a spoonful of sugar helps the medicine go down, and now researchers at Johns Hopkins have found that the sights and sounds of chirping birds, ribbiting frogs and water trickling downstream can ease the substantial pain of bone marrow extraction in one of five people who must endure it.

Substantial differences in bone marrow composition were observed, highlighted by an increase in adipocytes.

It was shown that a substantial increase in bone marrow FDG uptake is rapidly induced by CSF treatments and should not be misinterpreted as diffuse bone metastases or bone marrow disease [ 38].

In addition, local expression of TSLP under the control of a tetracycline-regulated, skin-specific promoter caused a substantial increase in bone marrow B lymphocytes and an earlier exodus of immature cells to the periphery [ 5].

In addition, substantial toxicity — particularly bone marrow and neurotoxicities — was evident with the higher-dose cisplatin treatment in both the above trials; to date, no large randomised studies evaluating a role for true high-dose chemotherapy have been performed.

This first study correlating histopathological changes in the spine of patients with AS with findings in MRI scans suggests that a substantial degree of bone marrow inflammation and edema is necessary to be detected by MRI.

Both factors also have hematopoietic roles, and are present in substantial amounts in the bone marrow, supporting the idea that neural and neuroendocrine factors have a direct effect on the bone microenvironment.

Adverse clinical prognostic factors include osseous metastases: substantial involvement of the bone marrow in infants, and any degree of distant bone marrow invasion in older patients.