Sentence examples for substantial binding affinity for from inspiring English sources

JB-788 was found to display substantial binding affinity for dopaminergic D2 receptors and, to a lesser extend to α1 adrenoreceptors.

c Targets detected with no significant binding affinity for CIS22a.

The compounds 24 26 demonstrated substantial binding affinity and selectivity for A2AR as compared to SCH58261, a standard A2AR antagonist.

These data indicate that residues forming the solvent-exposed side of APY derivatives bound to EphA4 could be modified without a substantial loss of binding affinity, for modifications such as peptide derivatization to improve pharmacokinetic properties.

Experiments suggest that there is indeed a substantial differential between the FIH binding affinity for non-CAD-hydroxylated versus CAD-hydroxylated ARs [ 13], and we predict that this difference is essential for achieving significant HIFα CAD-hydroxylation and the sharpest possible response curves.

The tested muscarinic agonists, [11C]xanomeline and [11C]butylThio-TZTP, appeared not selective for the M1ACh-R subtype and show high binding affinity for σ sites, leading to substantial non-selective binding.

Binding affinity in both human and canine prostate most significantly correlated with binding affinity for the recombinant bovine alpha-1C receptor (r =.98 human,.95 canine).

Results showed that Mini-B had a substantial binding (association) affinity for both DEPN-8 and DPPC based on a high uptake rate constant (kon) and a low dissociation rate constant (koff) (Table 2).

The presence of the toxic enzyme inside the cocoon is essential for its subnanomolar binding affinity for the TcA subunit.

Direct mutation of predicted interface residues confirmed that the protein had altered binding affinity for the mannose 6-phosphate receptor.

One mutant, MR1-1 scFv), had increased specific binding affinity for EGFRvIII.