Sentence examples for substantial binding affinity from inspiring English sources
The compounds 24 26 demonstrated substantial binding affinity and selectivity for A2AR as compared to SCH58261, a standard A2AR antagonist.
JB-788 was found to display substantial binding affinity for dopaminergic D2 receptors and, to a lesser extend to α1 adrenoreceptors.
c Targets detected with no significant binding affinity for CIS22a.
Results showed that Mini-B had a substantial binding (association) affinity for both DEPN-8 and DPPC based on a high uptake rate constant (kon) and a low dissociation rate constant (koff) (Table 2).
A functional role for oligomerisation is easy to rationalize: it combines the DNA-binding specificity of individual monomeric domains, leading to a substantial increase in binding affinity.
One of the key phenomena in the adaptive immune response to infection and immunization is affinity maturation, during which antibody genes are mutated and selected, typically resulting in a substantial increase in binding affinity to the eliciting antigen.
These data indicate that residues forming the solvent-exposed side of APY derivatives bound to EphA4 could be modified without a substantial loss of binding affinity, for modifications such as peptide derivatization to improve pharmacokinetic properties.
The N-termini of SYCP3 contain two conserved basic patches, BP1 52-KRRKKR-57 52-KRRKKR-57 52-KRRKKR-57landne mutation of BP2 88-KRKR-91 88-KRKR-91 88-KRKR-91P2, respectively) calanine substantial reduction in binding affinity, whilst mutation of BP1h patches (ΔBP1+2) corpletely eliminated DNA-BP2ding by SYCP3ΔCt6.
(B ) s34C (purple) does not confer substantial Pins-binding affinity on Anc-gkdup.
It is tempting to speculate that CD98 ecto-phosphorylation could have substantial effects on the binding affinity of CD98 for proteins expressed on the surface of other cells.
Despite the lack of perturbation of the iron sulfur cluster EPR signals in the presence of tyrosine, there was a substantial loss in substrate binding affinity in the variant proteins.
