The damage done to Marlborough's general standing was substantial because it was so visible.
Outdoor space in a downtown loft building, on the other hand, can command a substantial premium because it is so unusual.
First, the founders risk substantial dilution because it is often difficult for the founders and the investors to agree on a valuation for the startup and, accordingly, to agree on the percentage ownership the investor will receive.
Neospora has also generated substantial interest because it is an extremely close relative of the human pathogen Toxoplasma gondii, yet does not appear to infect humans.
Although these results may seem discouraging, we should consider that the use of self-reported diagnoses with low sensitivity but very high specificity in a cohort study do not represent a substantial drawback, because it is very likely that HT, as other chronic diseases, will end eventually showing themselves up during the follow-up of participants.
But the substantial form of a material compound, because it is predicated (accidentally) of the matter of the compound, is the cause of the compound's being the kind of thing that it is.
But male politicians also need something substantial on top, because it is assumed that a bald man cannot win a UK general election.
Although <200 cases of GAE have been described worldwide, it is still of substantial medical relevance because it is usually fatal due to diagnostic difficulties (9, 10 ) and lack of effective treatment.
Although two research groups have tried to generate the extracellular domain of TLR4 protein as a decoy receptor for MD-2 [20], [20], it proved difficult to generate a substantial amount of the protein because it is insoluble, its production rate is extremely low, and it is hard to purify due to its intrinsic biochemical properties.
This second effort, though more versatile, was also a substantial disadvantage because it was less efficient and often too slow to follow the moving front-line units.
